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KMID : 0379520160320020109
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한국독성학회지
2016 Volume.32 No. 2 p.109 ~ p.114
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External Application of Apo-9′-fucoxanthinone, Isolated from Sargassum muticum, Suppresses Inflammatory Responses in a Mouse Model of Atopic Dermatitis
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Han Sang-Chul
Kang Na-Jin
Yoon Weon-Jong
Kim Se-Jin
Na Min-Chull
Koh Young-Sang
Hyun Jin-Won
Lee Nam-Ho
Ko Mi-Hee
Kang Hee-Kyoung
Yoo Eun-Sook
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Abstract
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Allergic skin inflammation such as atopic dermatitis is characterized by skin barrier dysfunction, edema, and infiltration with various inflammatory cells. The anti-inflammatory effects of Apo-9′-fucoxanthinone, isolated from Sargassum muticum, have been described in many diseases, but the mechanism by which it modulates the immune system is poorly understood. In this study, the ability of Apo-9′-fucoxanthinone to suppress allergic reactions was investigated using a mouse model of atopic dermatitis. The Apo-9′-fucoxanthinone-treated group showed significantly decreased immunoglobulin E in serum. Also, Apo-9′-fucoxanthinone treatment resulted in a smaller lymph node size with reduced the thickness and length compared to the induction group. In addition, Apo-9′-fucoxanthinone inhibited the expression of interleukin-4, interferon-gamma and tumor necrosis factor-alpha by phorbol 12-myristate 13-acetate and ionomycin-stimulated lymphocytes. These results suggest that Apo-9′-fucoxanthinone may be a useful therapeutic strategy for treating chronic inflammatory diseases.
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KEYWORD
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Apo-9′-fucoxanthinone, Atopic dermatitis, 2, 4-Dinitrochlorobenzene, Immunoglobulin E, Phorbol 12-myristate 13-acetate, Ionomycin
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